LEAD OPTIMIZATION

Lead Optimization

Mumbai Biocluster's lead optimization services focus on refining drug candidates to enhance efficacy, reduce toxicity, and improve pharmacokinetics. Their integrated approach accelerates the development of optimized leads, ready for preclinical and clinical evaluations.

Our Services Includes

01

High-Throughput Screening (HTS)

High-throughput screening (HTS) capabilities to rapidly test large libraries of lead compounds against specific biological targets.
Development and validation of custom assays, allowing for the efficient identification of lead candidates with the desired biological activity.

03

Structure-Activity Relationship (SAR) Analysis

in-depth Structure-Activity Relationship (SAR) analysis to refine and optimize lead compounds.
systematically modification of chemical structures to enhance potency, selectivity, and overall therapeutic index while reducing potential off-target effects.

02

PK and PD Optimization

Optimization of pharmacokinetic (PK) and pharmacodynamic (PD) profiles of lead compounds to ensure they have suitable absorption, distribution, metabolism, and excretion properties.
Optimizing dosing regimens, bioavailability, and half-life, as well as enhancing the therapeutic efficacy and safety profile of the candidates.

04

In Silico Modelling and Predictive Analytics

Computational modeling and predictive analytics services to simulate and predict the behavior of lead compounds in biological systems.
Molecular docking studies, pharmacophore modeling, and predictive ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis to identify and optimize the most promising candidates for further development.